Genomic characterization of Escherichia coli isolates from alpaca crias (Vicugna pacos) in the peruvian highlands: insights into functional diversity and pathogenicity

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dc.contributor.authorZapata, Celso
dc.contributor.authorRodriguez Perez, Lila Maciel
dc.contributor.authorRomero Avila, Yolanda Madedein
dc.contributor.authorCoila, Pedro
dc.contributor.authorHañari Quispe, Renán Dilton
dc.contributor.authorOros, Oscar
dc.contributor.authorZanabria, Víctor
dc.contributor.authorQuilcate Pairazaman, Carlos Enrique
dc.contributor.authorRojas Cruz, Diórman
dc.contributor.authorCruz Luis, Juancarlos Alejandro
dc.contributor.authorOrtiz Morera, Narda Cecilia
dc.contributor.authorEstrada Cañari, Richard
dc.date.accessioned2025-08-19T04:46:32Z
dc.date.available2025-08-19T04:46:32Z
dc.date.issued2025-06-30
dc.description.abstractDiarrhea in alpaca crias significantly impacts livestock health in high-altitude regions, with Escherichia coli as a common pathogen. This study analyzed 10 E. coli isolates from diarrheic and healthy alpacas using whole-genome sequencing to assess genetic diversity, virulence factors, and antibiotic resistance. Predominant sequence types (ST73, ST29), serotypes (O22:H1, O109:H11), and phylogroups (B2, B1, A) were identified. Virulence profiling revealed ExPEC-like and EPEC pathotypes, while resistance genes for β-lactams (blaEC-15), fosfomycin (glpT_E448K), and colistin (pmrB) were prevalent. These findings highlight the need for genomic surveillance and antimicrobial stewardship to manage E. coli infections in alpacas and reduce public health risks.
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dc.identifier.citationZapata, C., Rodriguez, L., Romero, Y., Coila, P., Hañari-Quispe, R. D., Oros, O., Zanabria, V., Quilcate, C., Rojas, D., Cruz, J., et al. (2025). Genomic characterization of Escherichia coli isolates from alpaca crias (Vicugna pacos) in the Peruvian Highlands: Insights into functional diversity and pathogenicity. Microorganisms, 13(7), 1533. https://doi.org/10.3390/microorganisms13071533
dc.identifier.doihttps://doi.org/10.3390/microorganisms13071533
dc.identifier.issn2076-2607
dc.identifier.urihttp://hdl.handle.net/20.500.12955/2823
dc.language.isoeng
dc.publisherMDPI
dc.publisher.countryCH
dc.relation.ispartofurn:issn:2076-2607
dc.relation.ispartofseriesMicroorganisms
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceInstituto Nacional de Innovación Agraria
dc.source.uriRepositorio Institucional - INIA
dc.subjectE. coli genetic diversity
dc.subjectantibiotic resistance in alpacas
dc.subjectvirulence factors in alpaca pathogens
dc.subjectDiversidad genética de E. coli
dc.subjectresistencia a antibióticos en alpacas
dc.subjectfactores de virulencia en patógenos de alpacas
dc.subject.agrovocgenómica, genomics, pathogenicity; patogenicidad
dc.subject.ocdehttps://purl.org/pe-repo/ocde/ford#4.02.02
dc.titleGenomic characterization of Escherichia coli isolates from alpaca crias (Vicugna pacos) in the peruvian highlands: insights into functional diversity and pathogenicity
dc.typeinfo:eu-repo/semantics/article

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