Yupa-Quichua, MáximoPalomino Espinoza, Claudio CarlosCondori Ataupillco, Leivi TatianaAlarcón Romani, Susan MilagrosRomero Chávez, Lorena EstefaniBautista, RolandoSolórzano Acosta, Richard Andi2026-09-252026-09-252026-07-28Yupa-Quichua, M., Palomino, C., Condori, T., Alarcón, S., Romero-Chávez, L. E., Bautista, R., & Solórzano, R. (2026). Comparative evaluation of liquid bio-inputs in compost-fertilized quinoa under inter-Andean valley conditions: beneficial microorganisms enhance yield and profitability. Frontiers in Sustainable Food Systems, 10, 1888827. https://doi.org/10.3389/fsufs.2026.18888272571-581Xhttp://hdl.handle.net/20.500.12955/3287The study was conducted at the Canaán Agrarian Experimental Station (INIA, Ayacucho, Peru) during the 2024–2025 growing season to compare the effects of three liquid bio-inputs—beneficial microorganisms (BM), effective microorganisms (EM), and biol—applied at 15 and 30% concentrations, on the yield and profitability of quinoa crops (Chenopodium quinoa Willd., cv. INIA 415–Pasankalla) fertilized with compost (6 t·ha⁻¹). Compost-only and unfertilised control treatments were also included. The experiment was arranged in a randomized complete block design with eight treatments and three replicates. The application of bio-inputs in combination with compost significantly increased aboveground dry biomass, with EM15% and BM15% showing the greatest increases (26.42 and 27.01%, respectively) compared with the control treatment. Regarding yield variables, BM30% achieved the highest values for panicle diameter (11.47 cm), panicle length (46.6 cm), grain weight per panicle (26.76 g), grain yield (2.06 t·ha⁻¹), and 1,000-seed weight (2.89 g). The lowest saponin content was recorded under BM30% (0.0001%), whereas BIOL15% and BIOL30% showed the highest values (14.25 and 14.27%, respectively). Economic analysis revealed that BM30% generated the highest net profit (S/11,047.89) and the greatest benefit-to-cost ratio (2.95). These results indicate that, under compost-based fertilization, the application of 30% BM outperformed EM and biol in enhancing both yield and economic profitability of quinoa cv. INIA 415–Pasankalla under inter-Andean valley conditions.application/pdfenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Beneficial microorganismsMicroorganismos benéficosBiolChenopodium quinoaCompostEffective microorganismsMicroorganismos eficientesInter-Andean valleysValles interandinosProfitabilityRentabilidadYieldRendimientoinfo:eu-repo/semantics/articlehttps://purl.org/pe-repo/ocde/ford#4.01.04https://doi.org/10.3389/fsufs.2026.1888827Quinua, Quinoa; Soil fertility, Fertilidad del suelo; Biofertilizers, Biofertilizantes; Andean region, Región andina; Organic fertilizers, Abono orgánico