Tauchen, JanBortl, LudvikHuml, LukasMiksatkova, PetraDoskocil, IvoMarsik, PetrPanduro Villegas, Pablo PedroBendezu Flores, YmberVan Damme, PatrickLojka, BohdanHavlik, JaroslavLapcik, OldrichKokoska, Ladislav2020-10-032020-10-032016-06-14Tauchen, J.; Bortl, L.; Huml, L.; Miksatkova, P.; Doskocil, I.; Marsik, P.; Panduro, P.; Bendezu, Y.; Van Damme, P.; Lojka, B.; Havlik, J.; Lapcik, O.; Kokoska, L. (2016). Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon. Revista Brasileira de Farmacognosia Volume 26, Issue 6, Pages 728-737. doi: 10.1016/j.bjp.2016.03.016https://repositorio.inia.gob.pe/handle/20.500.12955/1143Among 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC = 1062.9 and 645.9 ± 51.4 μg TE/mg extract, respectively), while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29 = 2.7 and 9.0 μg/ml, respectively). However, combinatory antioxidant/anti-proliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH = 903.8 and ORAC = 1024 μg TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8 μg/ml, respectively) and Inga edulis Mart., Fabaceae (DPPH = 337.0 and ORAC = 795.7 μg TE/mg extract; IC50 for Hep-G2 and HT-29 at 36.3 and 57.9 μg/ml, respectively). Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases.Introduction. Materials and methods. Results. Discussion. Conclusion. References.application/pdfenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/AntioxidantAnticarcinogenicPhenolic compoundsPlant extractsinfo:eu-repo/semantics/articleBiotecnología agrícola, Biotecnología alimentariaRevista Brasileira de Farmacognosiahttp://dx.doi.org/10.1016/j.bjp.2016.03.016