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Título : Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon
Autor : Tauchen, Jan
Bortl, Ludvik
Huml, Lukas
Miksatkova, Petra
Doskocil, Ivo
Marsik, Petr
Panduro Villegas, Pablo Pedro
Bendezu Flores, Ymber
Van Damme, Patrick
Lojka, Bohdan
Havlik, Jaroslav
Lapcik, Oldrich
Kokoska, Ladislav
Fecha de publicación : 14-jun-2016
Resumen : Among 23 extracts of medicinal and edible plants tested, Mauritia flexuosa L.f., Arecaceae, showed significant antioxidant ability (DPPH and ORAC = 1062.9 and 645.9 ± 51.4 μg TE/mg extract, respectively), while Annona montana Macfad., Annonaceae, demonstrated the most promising anti-proliferative effect (IC50 for Hep-G2 and HT-29 = 2.7 and 9.0 μg/ml, respectively). However, combinatory antioxidant/anti-proliferative effect was only detected in Oenocarpus bataua Mart., Arecaceae (DPPH = 903.8 and ORAC = 1024 μg TE/mg extract; IC50 for Hep-G2 and HT-29 at 102.6 and 38.8 μg/ml, respectively) and Inga edulis Mart., Fabaceae (DPPH = 337.0 and ORAC = 795.7 μg TE/mg extract; IC50 for Hep-G2 and HT-29 at 36.3 and 57.9 μg/ml, respectively). Phenolic content was positively correlated with antioxidant potential, however not with anti-proliferative effect. None of these extracts possessed toxicity towards normal foetal lung cells, suggesting their possible use in development of novel plant-based agents with preventive and/or therapeutic action against oxidative stress-related diseases.
Palabras clave : Antioxidant
Anticarcinogenic
Phenolic compounds
Plant extracts
Editorial : El Sevier
Citación : Tauchen, J.; Bortl, L.; Huml, L.; Miksatkova, P.; Doskocil, I.; Marsik, P.; Panduro, P.; Bendezu, Y.; Van Damme, P.; Lojka, B.; Havlik, J.; Lapcik, O.; Kokoska, L. (2016). Phenolic composition, antioxidant and anti-proliferative activities of edible and medicinal plants from the Peruvian Amazon. Revista Brasileira de Farmacognosia Volume 26, Issue 6, Pages 728-737. http://dx.doi.org/10.1016/j.bjp.2016.03.016
Descripción : 10 Páginas
URI : http://repositorio.inia.gob.pe/handle/inia/1143
metadata.dc.identifier.doi: 10.1016/j.bjp.2016.03.016
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